ISBN 978-0-7464-9551-9. A Puerto Rico cinco siglos de historia. Informativa,
Enero. 1998.
El Estado Libre Asociado de Puerto Rico, entre compromiso y desengaño.
By Donald J. Sigmund; Rodolfo Dorrego; Frank Mora Fontalba.The evolution of HIV drug resistance and therapeutic responses to anti-retroviral regimens.
The HIV epidemic in the United States is currently dominated by drug resistant viruses. Most HIV drug resistant mutations (DRMs) affect reverse transcriptase, and primary mutations affect regions V and I, with secondary mutations affecting regions V, II, and VI. The prevalence of HIV DRMs varies among populations, and is highest in patients initiating combination therapy with nucleoside analogues and protease inhibitors. Resistance to all but a few of the currently available drugs has emerged during the past decade. Frequent genotypic resistance testing is therefore needed to monitor the prevalence of HIV DRMs and guide the selection of regimens. Recent studies have also suggested that the presence of HIV DRMs at the initiation of antiretroviral therapy can lead to rapid disease progression in some patients.Rational design and synthesis of a multifunctional lactam library for overcoming drug resistance.
Drug resistance remains one of the most devastating obstacles to successful chemotherapy. Herein, a rational design and synthesis of a multifunctional lactam library is described. A library of 99,600 compounds was prepared, and 5000 compounds were screened against S. aureus, M. tuberculosis, K. pneumonia, E. coli and H. pylori. Finally, a promising multifunctional compound was identified for potential application in anti-drug resistance therapy. The findings of this study suggest that this library holds great potential for anti-resistance drug discovery.WASHINGTON (Reuters) - Two Republican senators filed a resolution on Friday to require the government to provide the National Archives with information about how the U.S. Department of Justice and FBI used information gathered by former British spy Christopher Steele during the 2016 campaign.
FILE PHOTO: Senator Lindsey Graham (R-SC) speaks to reporters in the Capitol subway area before U.S. President Donald Trump's joint address to a joint session of Congress in Washington, U.S. March 30, 2018. REUTERS/Yuri Gripas/File Photo
The resolution is seen as a bipartisan effort to
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